Som beskrevet ovenfor kan person opleve medicinoverforbrugshovedpine ved anvendelse af paracetamol i længere perioder ad gangen.I slutningen af 1800-tallet fandt en tysk kemiker ud af, at virkningen skyldes stoffet acetylsalicylsyre. Det fik lægemiddelfirmaet Bayer til at udvikle Aspirin og senere Kodimagnyl, der hurtigt blev en stor succes verde
Nonopioid therapies are favored for subacute and chronic agony. Clinicians must maximize usage of nonpharmacologic and nonopioid pharmacologic therapies as suitable for the particular ailment and patient and only look at initiating opioid therapy if anticipated Positive aspects for soreness and function are predicted to outweigh threats on the pati
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